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GCGR knockout mice had unusually high levels of plasma GLP-1, which was shown to be due to increased L-cell number induced by GLP-1 action, even though L-cells do not express GLP-1R 129

I still do maintenance cycles every few months now

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Interestingly, GLP-1Ra given to OVA-sensitized mice also depressed the activity of oligomerization domain-like receptor protein (NLRP)3, which induces airway inflammation and AHR in obesity by upregulating levels of IL-17 secretion by ILC3 via secretion of IL-1 [109,110,111]

GLOW is therefore focused primarily on regenerative biology, while KLOW adds an additional inflammation-focused component