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a 2025 systematic review in orthopaedic sports medicine (Vasireddi et al., SAGE Journals) confirmed preclinical support but noted the absence of randomized controlled trials in humans
The authors reported that in obese mice, daily AOD-9604 administration over 14 days produced significant reductions in body weight gain, decreases in adipose tissue mass, and increases in fat oxidation, with effect sizes comparable to those of full-length human growth hormone [1]
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