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Nevertheless, despite demonstrating potent in vivo effects, neither study performed side-by-side dose-response benchmarking against clinical ACE inhibitors (e.g., lisinopril or captopril) under identical assay conditions

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The observed differential mRNA and protein expression levels of GPX4 and TfR1 in vitro may bear clinical relevance when considering factors such as tumor heterogeneity and the wide-ranging therapeutic response of thyroid tumors harboring diverse mutational signatures