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Researchers may study how hormone-signaling timing aligns with circadian models in controlled experimental systems

In vitro , overexpression of PACS-2 in HK-2 cells restores reticulophagy via TFEB/family with sequence similarity 134 member B pathway ( Autophagy disruption is caused by multiple-level abnormalities in upstream signaling pathways (117, 152)

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Together, these chaperone systems constitute a multilayered defense network that buffers neurons against proteotoxic insults and delays disease progression