Ferroptotic cells release DAMPs (4-HNE, HMGB1, and dsDNA), which activate the TLR4-MyD88-NF-B and cGAS-STING-TBK1-IRF3 pathways in glia, driving the production of IL-1, IL-6, TNF-, and type I interferon (Wang et al., 2019
Use once daily at night for best results (can be used twice daily if your skin tolerates it)
These reactions often improve as the body adjusts
Patients with a history of pancreatitis, medullary thyroid carcinoma, or multiple endocrine neoplasia syndrome type 2 should avoid this medication
Its formula features glycerin, tea tree, and other soothing ingredients to cleanse skin and reduce the appearance of hyperpigmentation all without leaving it red or irritated