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A1c reflects changes after 8-12 weeks because it measures a 2-3 month average
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The conserved lysine residue N-terminal to the active site, Cys A , helix 1 and helix 3 as well as the -sheets of the thioredoxin fold are almost perfectly superimposed
The graphical abstract was created in BioRender
Some might notice improved skin glow within 2-4 weeks, while more visible brightness and even skin tone may take 6-12 weeks of regular use
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