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c The recommended dosage of 300 mg QW for pediatric subjects 1 to 11 years of age weighing 40 kg is based on modeled pharmacokinetic data to provide comparable exposures to the 300 mg QW dosage in adult and pediatric subjects 12 years of age and older weighing 40 kg with EoE

The pharmacologic effects of GLP-1 are noted in the next figure

Gastric sleeve surgery is a popular procedure for significant weight loss, but some patients may experience weight regain or may not lose weight as anticipated

The model quantifies mortality and morbidity improvements by calendar year, sex, and age directly attributed to the uptake of these medications for controlling weight in obese populations and for managing diabetes

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