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Material and methodsRegistration This meta-analysis was performed in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for reporting systematic reviews.12 This systematic review was registered in PROSPERO [CRD42023485460]
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In a pilot study run in 2001 that included 20 non-diabetic patients, a 4-month course of metformin was associated with an improvement in serum aminotransferase levels, insulin sensitivity, and liver volume detected with ultrasound (US) in patients with NAFLD
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Red or fresh blood in the stools (rectal bleeding), is a sign of bleeding from the lower GI tract (rectum and anus)
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