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the ranges quoted reflect typical supplement formulations rather than evidence-based efficacy targets

We also present emerging strategies to overcome resistance, including rational drug combinations, novel agents, microbiome modulation, adaptive and intermittent therapies and advanced drug delivery systems, each illustrated with representative clinical studies

Aberrant activation of signaling pathways and therapeutic implications Taken together, the aberrant activation of signaling pathways such as PI3K-AKT-mTOR, MAPK, NF-B, TGF-, Wnt/-catenin, JAK/STAT, Notch, Hippo-YAP/TAZ, and GAS6/AXL contributes extensively to therapy resistance across cancer types (Fig

Paul, S., Jakhar, R., Bhardwaj, M