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In UK clinical settings, the recognised standard diluent for injectable medicines is Water for Injections BP (single-use, preservative-free), and the choice of diluent must always follow the licensed product's Summary of Product Characteristics (SmPC)
Unfortunately, studies on this topic have mainly focused on normalising serum B12 concentrations with oral supplementation and should be interpreted with caution since the specific goal of treatment in symptomatic B12 deficiency is alleviating symptoms, and NOT to normalize B12 concentrations in the blood
10.3748/wjg.v22.i41.9127 15 DrmicD.KolencD.IlicS.BaukL.SeverM.SeverZ.et al (2017)
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Vit B12 injection is always given in the gluteal region due to large volume
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