Glutathione depletion as a mechanism of Parkinson's disease: midlife depletion in animals induces symptoms and disability www.sciencedaily.com Depleting glutathione may cause Parkinsons: Mice induced to have glutathione depletion as young adults did not develop Parkinsonian-like nerve damage and symptoms, while those who suffered from the depletion in late middle age did develop a loss of dopaminergic neurons specifically related to PD
That implies that increased skin deposition will be beneficial for topical agents
Barrier dysfunction is further characterized by reduced mucin content (40), diminished glucose-derived metabolites (41), impaired lipid-associated protective factors (42), and decreased secretion of pancreatic-derived defense molecules (43)
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The intranasal GHK-Cu treatment was found to delay cognitive impairment, reduce amyloid plaques, and lower inflammation levels in the frontal cortex and hippocampus .37 Randomized controlled trials in human patients are needed to confirm the benefit of GHK-Cu for cognitive decline and Alzheimers disease as well as to evaluate safe and effective human dosing (the human dose equivalent of 15mg/kg in mice would be ~1.2mg/kg, though data on this or any other dosing nasally in humans is not currently available), but preliminary animal trials are promising