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Overall our findings, exploring BChE activitys validity as a biomarker of a depressive state using in vitro psychological stress models with corticosterone and norepinephrine exposure in PC-12 Adh cells, indicate that the decrease in BChE activity with corticosterone treatment reflects depressive states, while the reversal by fluoxetine supports its antidepressant effects

Cell Host Microbe 32 , 13651379.e10 (2024)