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RMD Open (2016) 2(2):e000289
A third mechanism of action is through the deconjugation of bile acids, which are the acids that come from your liver
Here, we demonstrate that the effects of cotadutide in reducing body weight and food intake and improving glucose control are predominantly mediated through Glp-1 signalling, whereas its action on the liver to reduce lipid content, drive glycogen flux and improve mitochondrial turnover and function are directly mediated through Gcg signalling
Some populations, such as adolescents with migraine who suffer from comorbid obesity, may be of interest for further study, as GLP-1 agonists could potentially relieve pain while also addressing obesity [59]
However, when present in excess, it contributes to the development of fatty deposits in the arteries, which can restrict blood flow and lead to serious health issues such as heart attacks and ischemic strokes [1][2]
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