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In a study of pivotal trials supporting FDA approvals from 2017 to 2023, which included US and international recruitment, only 6% achieved enrollment aligned with the four largest US racial and ethnic groups' population shares ( [2] ), and Black and Hispanic enrollment declined over the study period ( [3] )

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The owners knew the contribution margin ratio and all fixed costs from the financial model

Increased BBB permeability induced by mannitol had no significant effect on inflammation and dendritic spines in healthy mice but triggered a marked de-ramification of microglia