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Seek urgent same-day assessment or call 999 for emergency care if experiencing: Severe chest pain Severe shortness of breath Fainting or collapse Acute or rapidly worsening neurological deficits (such as new limb weakness, sudden gait disturbance, or bladder/bowel dysfunction) Persistent or worsening anaemia symptoms despite treatmentincluding breathlessness, chest discomfort, palpitations, or extreme fatigueshould trigger medical review

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[1] [2] Persistent gastrointestinal symptoms can lead to reduced nutritional intake, dehydration, and electrolyte disturbances, all of which may present as fatigue

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The reduced form accounts for the majority and plays a key role under physiological conditions