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Compared with other CVOTs involving GLP-1RA, participants in the AMPLITUDE-O trial had the longest duration of diabetes (15 years), lowest mean eGFR (72 ml/min/1.73 m 2 ) with a higher percentage (32%) of people with renal disease (eGFR 2560 mL/min), highest glycosilated hemoglobin (8.9%), and highest percentage of insulin use (62%) or sodiumglucose transporter-2 inhibitors (SGLT-2i) (15%) at baseline, thus identifying a more fragile population

Run retatrutide alone for the first 8 weeks, then add cagrilintide at the lowest dose (0.25 mg)

It can be re-added later if needed

Prim Care Diabetes (2017) 11:312

Steroids can promote muscle gain because they target protein synthesis, control fat percentage, and faster recovery from exercise