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The overall rate of GSH synthesis is controlled by several factors including: (i) availability of the substrate mainly L-cysteine (Taylor et al., 1996)

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A double-blind, randomized phase 2 study comparing various doses (1, 5, 10, 15 mg) of once weekly tirzepatide, dulaglutide (1.5 mg) and placebo, in patients with T2DM, showed tirzepatide was superior on weight loss and glucose-lowering compared to both dulaglutide and placebo [52]

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