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Mutation of a nicotinic acetylcholine receptor subunit is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae
Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H (1998) Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
The short answer is that traditional oral glutathione has very low bioavailability
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