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Zhao J, Ouyang Y, Wang H, Lai H, Hu S, Tang L, et al

Conversely, TLR8 and TLR9 are preformed dimers, where ligand attachment triggers conformational adjustments

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Moreover, twin-like charge-switchable nanoparticles shMFN1-NPs + DOX-NPs (MIX-NPs) can selectively target TAMs and cancer cells and deliver shMFN1 by inhibiting mitochondrial fusion, which can not only restructure M2 TAMs to the M1 TAMs but also promote DCs maturation and CD8 + T cells infiltration and activation and inhibit MDSCs and Tregs, showing strong anti-tumor efficacy (221)