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Thus, MET signaling is implicated not only in neuronal growth and maturation but also in the timing regulation of synaptic plasticity during forebrain glutamatergic circuit development ( Mechanistically, HGF-induced synapse formation is mediated by PI-3K and not MAPK activation, as inhibition of the PI-3K/AKT pathway affects synaptogenesis, while blocking MAPK/ERK does not decrease synapse density and only affects dendritic growth ( Implications of HGF-MET Gene Mutations in NDDs MET has an important role in neuron architecture construction and synapse maturation, as described in previous sections
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Lipogenesis Inhibition: In adipose tissue, NNMT inhibition reduces lipid accumulation by up to 70% (in vitro), shifting the cell's priority from fat storage to energy expenditure
SC injection is often preferred by patients who self-administer at home due to the shorter needle length and reduced depth of injection, which many find less intimidating