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A dose escalation trial in 24 adults found that single oral dosages up to 12 g were safe, and adverse effects, including diarrhea, headache, rash, yellow stool, were not related to dose (7)
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KFF News reports that this survival benefit was mainly seen in patients with a body-mass index (BMI) over 35, indicating that the protective effect might be related to the metabolic and weight-related changes associated with GLP-1 use
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