239 Treatment with MAT2A inhibitors AG-24152 and AG-270 significantly reduces SAM levels, inhibits PRMT5 activity, and causes DNA damage and mitotic defects in tumor cells
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93 After using guinea pig asparaginase 1 (gpASNase1) to promote the conversion of Asn to Asp in tumor cells, the growth rate of tumor cells was significantly increased, suggesting that Asp acquisition is an endogenous metabolic limitation in tumors with difficult Asp acquisition
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