Ough, M
Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure
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Materials and Methods Chemicals, Antibodies, and Reagents Optima LC grade acetonitrile was purchased from Merck (Merck, Darmstadt, Germany), formic acid was purchased from Fluka (Honeywell, Morris Plains, NJ, United States), and ultrapure water was prepared using a Milli-Q purification system (Merck Millipore, Darmstadt, Germany)
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