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First-in-Human trials follow a cautious and progressive dose-escalation approach designed to support continuous safety evaluation throughout the study

PubMed: 16172515 Ipamorelin in GH-Deficient Populations: Therapeutic Efficacy human pilot Svensson J, Johannsson G, Bengtsson BA, et al

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These studies indicate the potential of utilizing the de novo pathway, a less extensively studied pathway, as a therapeutic strategy for metabolic diseases Barth syndrome is a rare disease caused by mutations in the tafazzin gene encoding for cardiolipin (CL), a phospholipid specific for the mitochondria 303