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A pivotal point early on in this research was the use of the known peptide sequence of glucagon to facilitate the discovery of other glucagon-like peptides in the gastrointestinal tract with the help of the radioimmunoassay method ( Figure 1 )
[10] The modifications, however, were not regarded as clinically important
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ABSTRACT Background Glucagon-like peptide-1 (GLP-1) is an incretin known for its anti-obesity effects, and several effective drugs targeting GLP-1 receptors (GLP-1Rs) have recently been developed to treat obesity
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