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Additionally, vitamin B12 deficiency can cause paresthesia or numbness in the limbs

Profiling the gasdermin D-targeting proteases also illuminated why variants evolved on GD_Sh were able to pass PACE selection but failed to cleave longer gasdermin D substrates in vitro

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Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use