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Protein is non-negotiable GLP-1 agonists cause weight loss through multiple mechanisms, but not all weight loss is equal

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While GLP-1 drugs have shown significant benefits, new concerns have arisen about potential side effects, particularly the risk of developing blood clots, that can lead to deep vein thrombosis (DVT) and pulmonary embolism (PE)

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GLP-1 receptor agonists and GLP-1 and glucose-dependent insulinotropic peptide agonists have several mechanisms of action, including reduction of gastric emptying, inhibition of glucagon secretion, beneficial changes in the intestinal microbiome, and direct effects on hypothalamic nuclei to enhance satiety (which promotes weight loss)