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128 Psychotherapeutic interventions such as cognitive behavioral therapy (CBT) have proven efficacy as stand-alone treatment for mild depression and alongside drug therapy in moderate-to-severe cases

The keratinocytes within the basal and spinous layer of the oral epithelium synthesize 1,25-dihydroxyvitamin D (1,25(OH)D) and vitamin D receptor (VDR) is expressed within the cells

William Castle demonstrated that gastric juice contained an "intrinsic factor" which when combined with meat ingestion resulted in absorption of the vitamin in this condition

The phase 3 REDEFINE 1 trial expanded on these findings dramatically

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