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Advanced Dosing Protocol Experienced peptide users with established tolerance may utilize higher doses for maximum effect: Total daily dose : 600-1000mcg (300-500mcg each peptide) Frequency : 5-6 days per week Administration : Single evening dose or split AM/PM dosing Cycle length : 12-16 weeks followed by 4-8 week break Important note : Higher doses don't always equal better results
Notably, the PFKFB3 inhibitor 3PO was shown to increase vessel integrity and enhance tumor perfusion, resulting in decreased hypoxia and increased drug delivery (132)
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