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Gene expression studies reveal modulation of 408 neuronal genes, including dramatic increases in OPRM1 (opioid receptor, up 1,294%), KCND1 (up 845%), and SLC8A2 (up 737%)
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Glutathione peroxidase 1 (GPx1) is the most abundant version, existing in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide
Forced expression of these miRNAs in prostate cancer cells, PC3 and LNCaP, results in reduced expression of CPT1A, CAC, and CAT, and hence, negatively affects FAO
in the model we assume that these two rates balance
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