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The math: Standard schedule: 4 doses over 28 days Consistent one-day-early schedule: 4 doses over 24 days Effective dose increase: approximately 17% This is how patients unintentionally escalate their dose without realizing it
Notably, the voltage-dependent anion channel (VDAC) in the mitochondrial outer membrane, also known as the mitochondrial pore, acts as a gatekeeper for the entry and exit of mitochondrial metabolites and is a convergence point for its binding to various ligands and proteins to mediate various cell survival and cell death signals [47]
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J Med Chem 10-21-2004;47(22):5555-5566
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