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10.1021/acs.molpharmaceut.9b00132 Mol
Parallel to the findings from rat liver mitochondria, it has been recently reported that mitochondrial cholesterol enrichment, resulting in mGSH depletion, is a major mechanism of anthrax lethal toxin-induced macrophage cell death (Ha et al., 2012)
The study reported lower risks for several cancers, including hepatocellular, colorectal, breast, and prostate cancers, though it did not find a significant reduction in lung cancer risk.25 So the honest answer is this: current human evidence does not show that NAC causes cancer, but animal and mechanistic research suggests NAC could behave differently depending on cancer type, disease stage, dose, and treatment context
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Now, go make some sensitive souls feel absolutely fabulous.
