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In December 2024, the FDA approved Zepbound (tirzepatide) for moderate-to-severe obstructive sleep apnea in adults with obesity, used alongside a reduced-calorie diet and more physical activity
These data may be suggestive of developments in pancreatic -cell function because increased circulating proinsulin/insulin ratios and proinsulin/C-peptide are important markers of initial and increasing pancreatic -cell secretory dysfunction
The data are not publicly available due to ethical restrictions
For example, deeper slow-wave sleep is associated with improved hormone regulation such as growth hormone (GH) release, which supports tissue repair and metabolic health
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