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The Journey Card becomes a clinical quality of life and safety record that you and your clinician can use during long-term follow-up

Some allow free pausing or canceling, while others charge fees for account changes or require advance notice (30 days is common)

Therefore, potential sex-related differences in the effectiveness or tolerability of dose escalation could not be assessed, and the applicability of these findings across women and men should be interpreted with caution

Case in point: your liver

Discuss contraception options with your healthcare provider, as additional contraception is needed for 4 weeks after starting treatment and after each dose increase, or non-oral methods should be considered