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Indication-specific advantages: Glucagon co-agonists such as survodutide, mazdutide, and retatrutide may have superior hepatic effects in MASH and MASLD because glucagon acts directly on liver lipid metabolism

The methylation cycle is entirely dependent on a steady supply of specific B-vitamins acting as coenzymes, particularly Vitamin B9 (folate), Vitamin B12 (cobalamin), Vitamin B6, and Vitamin B2 (riboflavin)

They slow gastric emptying, enhance satiety, reduce hunger, and improve glycemic control in patients with type 2 diabetes

This is sometimes done when the initial solution is too concentrated for accurate dosing

Return of Cravings Some patients notice an increase in cravings, particularly for highly processed or energy dense foods