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In addition to glutamate receptor modulation by agonists, antagonists, and negative allosteric modulators, drugs or agents can be developed that can inhibit glutamate release, facilitate the clearance of glutamate by excitatory amino acid transporters, and modulate the voltage gated Na + channels that are involved in glutamate regulation (Fig

None of them are uncommon

449 Nevertheless, the clinical implementation of predictive biomarkers faces challenges, including assay standardization, sampling heterogeneity, detection sensitivity/specificity, and incomplete mechanistic understanding

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