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J Affect Disord 136:933939 Mahmoudi M, Bayat AH, Boroujeni ME et al (2019) Curcumin protects purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-AP

The compound's tolerability is fine

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the 1 mg arm is the lowest measured human pharmacologic activity: Frias Lancet 2018

hair loss, lethargy, weakness, etc