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MOTS-C is a mitochondrial-derived peptide with AMPK-activating properties studied in metabolic research
Nat Rev Mol Cell Biol 25(6):424442 Wen Q, Liu J, Kang R, Zhou B, Tang D (2019) The release and activity of HMGB1 in ferroptosis
These radicals are found to be toxic to macromolecules such as proteins, lipids, and DNA
Network modeling Graph neural networks and other advanced computational tools now enable simulations wherein perturbation of a single node, for example, HSP90 inhibition, can be computationally modeled to predict downstream shifts in UPS engagement or autophagy induction
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