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Impact on appetite and weight loss GLP-1 agonists activate GLP-1 receptors in the brain, signalling the central nervous system to reduce appetite and enhance satiety

From there, any future change is easy to spot and act on

A paradigm shift in how PCOS is understood: The 2025 Lancet Diabetes & Endocrinology Commission explicitly reframed PCOS as a complication of obesity rather than a standalone reproductive condition

Metformin is recommended in adults with PCOS and a BMI 25 to improve insulin resistance, glucose and lipid profiles, but not for weight loss [161]

Anatomy, biogenesis and regeneration of salivary glands