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Dual GIP/GLP-1 agonists now represent the highest-revenue growth segment in the GLP-1 weight loss drug market at 18.4% CAGR , with tirzepatide generating USD 18.3 billion in 2025 revenue through Zepbound and Mounjaro surpassing Eli Lillys entire insulin franchise within two years of commercial launch

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Based on these observations, an ADC conjugated to duocarmycin through a cleavable enzymatic linker was designed against the B2M protein and used as a senolytic therapy

Zhang K, Zhu J, Wang R, Gong L,Feng F, Liu WHL, Qu W

Reproductive Biology Endocrinol