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Once senescent cells are removed, the downstream benefits continue to develop as: SASP-driven inflammation progressively resolves Stem cell niches, previously suppressed by SASP factors, may reactivate Tissue remodeling and repair processes engage in cleared areas The paracrine senescence cascade (where SASP converts healthy cells to senescent ones) is interrupted In mouse models, improvements in kidney function and physical fitness persisted and in some cases continued to develop during the weeks following treatment cessation (Baar et al., 2017)

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Adding to the complexity, if the viral glycoprotein cross-seeds an endogenous brain protein, years later even the viral protein need not be present, as the run-away proteopathy would now involve only endogenous brain protein (s)

Similarly, TB-500 has undergone extensive safety evaluation including human research trials showing safety at intravenous doses up to 1,260 mg equivalent, with no dose-limiting toxicities or serious adverse events attributable to the peptide in carefully controlled studies

and travel, accommodations, expenses from AstraZeneca, Roche, Novartis, prIME Oncology, Pfizer