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Glutamate neurotransmission plays a significant role in modulating synaptic activity during nervous system development ( Enzyme histochemistry has shown that GDH is present in rat hippocampal dendritic layers and that GDH activity increases in tandem with the postnatal maturation of synaptic structures (Schnzel and Wolf, 1982)

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A similar lower risk for recurrent CUD was observed in patients with and without obesity, though not statistically significant in patients without obesity (Fig