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EMERGING RESEARCH: WHAT THE SCIENCE SAYS While we are still awaiting large-scale clinical trials specifically for lipedema, recent pilot studies and reviews are promising: The "Italian Pilot Study" (Exenatide): A recent pilot study looked at women with lipedema and insulin resistance treated with a GLP-1 agonist (exenatide)
ACE2 enzyme degrades ANG II, the major effector of the RAAS that increases hypertension (by lowering baroreceptor sensitivity) to control heart rate, up-regulate vasoconstriction, sodium retention, OxS, inflammation, and fibrosis 300
It increased cellular 'stemness' and activated multiple repair pathways simultaneouslysuggesting it works as a broad biological reset signal
Lee H, Kim D, Youn B
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