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One study found that after injecting high doses of vitamin B12 (specifically cyanocobalamin) into rodents, the B12 stayed in the bloodstream for a relatively short period, with a half-life ranging from 20 to 50 minutes
This can lead to an uneven concentration in the vial, which compromises its reliability for consistent dosing.
Moreover, as pointed by Martins-Filho et al
Vitamin B12 Overdose in a Vegan Diet Long-term implementation of the vegan diet without taking vitamin B12 supplements is strongly correlated with a deficiency
