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Lee JY, Kang DH, Chung DY, Kwon JK, Lee H, Cho NH, et al

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Of the older therapies, sulphonylureas, insulin and glitazones are all associated with significant weight gain, whereas metformin is associated with slight weight loss

Germ-free mice orally administered with IBD patient saliva containing Klebsiella aeromobilis developed colitis by inducing the accumulation of intestinal T helper 1 cells, while the inflammatory state in IBD may render the intestine more permissive to aerotolerant oral-derived bacteria than the steady-state intestine ( in vivo pathogenicity threshold of translocated oral bacteria in humans, and the mechanistic interplay between oral pathobiont virulence upregulation and gut mucosal invasion