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Unpredictable Allergic Reactions and Hives (MCAS): Oxidative stress acts as a direct trigger for mast cell degranulation
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Pathway / mechanism context Successful wound healing depends on fibroblasts (which regulate the production of extracellular matrix) and immune system cells
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Supporting phase II detox of the 2-OH and 4-OH metabolites The 2-OH and 4-OH estrogen metabolites are cleared out in phase II primarily through methylation , which is carried out by the catechol-o-methyltransferase (COMT) enzyme
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