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This process has two phases

Speichinger, hormonal imbalances can be caused by a number of different health conditions: thyroid disease like hyperthyroidism or hypothyroidism, polycystic ovary syndrome (PCOS), primary ovarian insufficiency, and hyperprolactinemia, or having too much of a hormone called prolactin in your blood

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DA in the synaptic cleft is taken up by the surrounding astrocytes where DA is degraded into its metabolites through reactions catalyzed by monoamine oxidases (MAOs) and catecholamine-O-methyltransferase (COMT) [29]