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Mechanisms affecting BBB to neurodegeneration Neurodegenerative diseases such as AD, PD, ALS, and MS, while distinct in clinical presentation, share a convergence on impaired BBB stability, CBF reduction, and vascular inflammation, reflecting parallel paths of progressive neurodegeneration distinct from acute brain injuries

Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis

All preclinical data is consistently positive across musculoskeletal, GI, and neurological outcomes

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Loading and maintenance: Higher initial doses tapering to maintenance levels