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doi: 10.3390/nu13072473

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It is known that the CV protection effect of GLP-1RAs have been proven through eight large-scale clinical studies, including Evaluation of LIXisenatide in Acute coronary syndrome (ELIXA) [66], LEADER [44], Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN)-6 [67], Exenatide Study of Cardiovascular Event Lowering (EXSCEL) [68], Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes) [69], Researching Cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) [70], Peptide Innovation for Early Diabetes Treatment (PIONEER) 6 [67,71], and AMPLITUDE-O [51]

Debes llamar al 911 o acudir inmediatamente al departamento de emergencias si experimentas fatiga severa acompaada de sntomas como confusin, mareos intensos, desmayos, palpitaciones cardacas, dolor en el pecho, dificultad para respirar, hinchazn facial/labial/garganta o urticaria, ya que estos pueden indicar complicaciones graves como hipoglucemia severa, deshidratacin significativa o reaccin alrgica