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Left panel (Mechanism of Action & Pharmacodynamics) : Imipramine inhibits the serotonin transporter (SERT) and norepinephrine transporter (NET), resulting in increased synaptic concentrations of serotonin and norepinephrine (dual monoamine reuptake inhibition)

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Interestingly enough, in 6-OHDA rats, the dual GLP-1/GIP agonist (DA5-CH), in addition to promoting the survival of dopaminergic neurons, was able to reduce the levels of monomer and oligomers of -synuclein, thus providing a wider neuroprotective effect [53]

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